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Que es la dieta cetogenica wikipedia

Compartir en. Crea Que es la dieta cetogenica wikipedia cuenta o Conectarse. Expert tip 6: Learn ListPages - arguably the most powerful Que es la dieta cetogenica wikipedia available. Possible negative interaction between ketogenic diet and erlotinib I do not have any confirmation of the truth of these arguments. Cotreatment of Erlotinib with inhibitors of mitochondrial oxidative phosphorylation significantly blocks erlotinib-induced activation of BAX and BAK and cell death [1]. Ketogenic diets produce gluconeogenesis, which leads to the formation of oxaloacetate. Oxaloacetate is an inhibitor of oxidative phosphorylation [2],[3]. Therefore, ketogenic diet may block Erlotinib-induced apoptosis. Glucose deprivation increases tyrosine kinase signaling. Glucose withdrawal activates a positive feedback loop involving generation of reactive oxygen species ROS by NADPH oxidase and mitochondria, inhibition of protein tyrosine phosphatases by oxidation, and increased tyrosine kinase signaling, ultimately resulting in ROS-mediated cell death [4]. Erlotinib is a tyrosine kinase inhibitor. Free radicals Ketogenic diet generates free radicals and this induces TACE activation which antagonizes Erlotinib action by inducing EGFR-1 independent tumor growth hence, worsening resistance to Erlotinib.

What is Que es la dieta cetogenica wikipedia ketogenic diet? Open in a separate window. The discovery of ketogenic diets as a disease therapy Que es la dieta cetogenica wikipedia Hippocrates, prolonged periods of fasting have been recorded as a therapeutic tool for Que es la dieta cetogenica wikipedia [21].

Clinical applications of ketogenic diet Increased recognition of the safety and efficacy of using ketogenic diets in the treatment of epilepsy has resulted in successful application of this dietary intervention to other disorders. Ketogenic diets in cancer therapy Recently, ketogenic diets have been studied as an adjuvant to cancer therapy in both animal models and human case reports. Proposed mechanism of action of ketogenic diet in cancer Mitochondrial metabolism and cancer Most cancer therapies are designed to take advantage of the metabolic and physiological differences that exist between cancer cells and normal cells.

Glucose dependence of cancer cells Glycolysis mediates the enzymatic breakdown of glucose to pyruvate, which in the presence of oxygen is converted to acetyl-CoA and enters the Citric Acid Cycle in the mitochondria.

Ketogenic diets increase cancer cell oxidative stress Ketogenic diets may act as an adjuvant cancer therapy by two different mechanisms that both increase the oxidative stress inside cancer cells. Potential risks Que es la dieta cetogenica wikipedia ketogenic diets Ketogenic diets haves been recognized to be effective at controlling seizures and inducing weight loss but have been suggested to cause Dietas rapidas potential side effects.

Possible acute and chronic side effects associated with the ketogenic diet. Clinical trials using the ketogenic diet for cancer control There are currently 62 trials assessing low carbohydrate diets as a potential therapy for a variety of diseases of which 11 trials are assessing ketogenic diets as an adjuvant cancer therapy. Conclusions Despite recent advances in chemo-radiation, the prognosis for many cancer patients remains poor, and most current treatments are limited by severe adverse events.

Conflict of interest The authors declare that they have no conflict of interest.

Que es la dieta cetogenica wikipedia

Acknowledgements The authors would like to thank the manufacturers of KetoCal for providing their diet formulation for ongoing pre-clinical and clinical trials. References 1.

Keto Diet For Fast Weight Management

Warburg O. On the origin of cancer cells. Ahmad I. Journal of Biological Chemistry. Aykin-Burns N. Increased Que es la dieta cetogenica wikipedia of superoxide and H 2 O 2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation.

Biochemical Journal. Spitz D. Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism?

Que es la dieta cetogenica wikipedia

Annals of the New York Academy of Sciences. Allen B. Ketogenic diets enhance oxidative stress and radio-chemo-therapy Que es la dieta cetogenica wikipedia in lung cancer xenografts. Clinical Cancer Research: ; 19 14 — Bize I.

Superoxide dismutase and superoxide radical in Morris hepatomas. Cancer Research. Coleman Dietas faciles. Dixon S. The role of iron and reactive oxygen species in cell death.

Nature Chemical Biology. Fath M. Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism.

Clinical Cancer Research: ; 17 19 — Mitochondrial electron transport chain blockers enhance 2-deoxy- d -glucose induced oxidative stress and cell killing in human colon carcinoma cells.

Hadzic T. Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H 2 O 2 -mediated oxidative stress. Ishikawa K. Oberley L. Anticancer therapy by overexpression of superoxide dismutase. Mechanism of the tumor suppressive Adelgazar 72 kilos of MnSOD overexpression.

Springer E. Comparative study of the cytoplasmic organelles of epithelial cell lines derived from human carcinomas and nonmalignant tissues. Wen S. Targeting cancer cell mitochondria as a therapeutic approach. Future Medicinal Chemistry.

Wondrak G. Redox-directed cancer therapeutics: molecular mechanisms and opportunities. Westman E. The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic Dietas faciles in type 2 diabetes mellitus.

Valayannopoulos V. Successful treatment of severe cardiomyopathy in glycogen storage disease type III with D, l hydroxybutyrate, ketogenic and high-protein diet. Pediatric Research. Gilbert D. The ketogenic diet: seizure control correlates better with serum beta-hydroxybutyrate than with urine ketones. Journal of Child Neurology. Wheless J. History and origin of the ketogenic diet. In: Stafstrom C. It is based on the assumption that Adelgazar 20 kilos the method our cavemen forefathers did, i.

The ketogenic diet plan is particularly a "recovery" diet regimen that is meant to profit the body in several ways and aid protect against conditions. The paleo diet regimen does not do that. Also, the paleo diet plan is based upon eating Que es la dieta cetogenica wikipedia rather than manipulating the proportion of fats, carbs, and healthy protein to attain a ketonic state that makes use of fat as fuel.

There is a reason the ketogenic diet has actually become so preferred. That's what makes the keto diet regimen so unique and also successful. Esto, junto al incremento de cetonas, proporciona numerosos beneficios Que es la dieta cetogenica wikipedia la salud.

Algunos estudios han demostrado que la dieta puede tener Que es la dieta cetogenica wikipedia en una gran variedad de enfermedades:. Intente variar entre las verduras y carne durante una temporada larga, ya que cada uno proporciona nutrientes diferentes y beneficios para la salud. Puede pedirse alguno de estos alimentos y reemplazarlos por cualquier comida rica en carbohidratos con extra de verduras.

Otro plato ideal es una hamburguesa poco hecha. En los restaurantes mexicanos, puede disfrutar de cualquier tipo de carne con extra de queso, guacamole, salsa y crema agria. Crea la cuenta o Conectarse.

Expert tip 6: Learn ListPages - arguably the most powerful module available. Possible negative interaction between ketogenic Que es la dieta cetogenica wikipedia and erlotinib I do not have any confirmation of the truth of these arguments. These studies generally examined a cohort of patients recently treated by the physician a retrospective study and selected patients who had successfully maintained the dietary restrictions.

However, these studies are Que es la dieta cetogenica wikipedia to compare to modern trials. One reason is that these older trials suffered from selection biasas they excluded patients who were unable to start or maintain the diet and thereby selected from patients who would generate better results. In an attempt to control for this bias, modern study design prefers a prospective cohort the patients in the study are chosen before therapy begins in which the results are presented for all patients regardless of whether they started or completed the treatment known as intent-to-treat analysis.

Another difference between older and newer studies is that the type of patients treated with the ketogenic diet has changed over time. When first developed and used, the ketogenic diet was not a treatment of Que es la dieta cetogenica wikipedia resort; in contrast, the children in modern studies have already tried and failed a number of anticonvulsant drugs, so may be assumed to have more difficult-to-treat epilepsy. Early and modern studies also differ because the treatment protocol has changed.

Concerns over child health and growth led to a relaxation of the diet's restrictions. A study with an intent-to-treat prospective design was published in by a team from the Johns Hopkins Hospital [20] and followed-up by a report published in The study enrolled children. Those who had discontinued the diet by this stage did so because it was ineffective, too restrictive, or due to illness, and most of those who remained were benefiting from it.

Que es la dieta cetogenica wikipedia

During this period, the most common reason for discontinuing the diet was because the children had become seizure-free or significantly better. Those remaining on the diet after this duration were typically not seizure-free, but had had an excellent response.

Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism

It is possible to combine the results of several small studies to produce evidence that is stronger than that available from each study alone—a statistical method known as meta-analysis. One of four such analyses, conducted inlooked at 19 studies on a total of 1, patients. A Cochrane systematic review in found and Que es la dieta cetogenica wikipedia eleven randomized controlled trials of ketogenic diet in people with epilepsy for whom drugs failed to control their seizures.

The other trials compared types Adelgazar 10 kilos diets or ways of introducing them to make them more tolerable.

A systematic review in looked at 16 studies on the ketogenic diet in adults. It concluded that the treatment was becoming more popular for that group of patients, that the efficacy in adults was similar to children, the side effects relatively mild.

However, many patients gave up with the diet, for various Que es la dieta cetogenica wikipedia, and the quality of evidence was inferior to studies on children.

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Health issues include high levels of low-density lipoproteinhigh total cholesterol Dietas faciles, and weight loss. The ketogenic diet is indicated as an adjunctive additional treatment in children and young people with drug-resistant epilepsy.

Some clinicians consider the two less restrictive dietary variants—the low glycaemic index treatment Que es la dieta cetogenica wikipedia the modified Atkins diet—to be more appropriate for adolescents and adults. These include Dravet syndromeinfantile spasmsmyoclonic-astatic epilepsyand tuberous sclerosis complex.

Several possible explanations exist for this gap between evidence and clinical practice. Because the ketogenic diet alters the body's metabolism, it is a first-line therapy in children with certain congenital metabolic diseases such as pyruvate dehydrogenase E1 deficiency and glucose transporter 1 deficiency syndrome[35] which prevent the body from using carbohydrates as fuel, leading to a dependency on ketone bodies.

The ketogenic diet is beneficial in treating the seizures and some other symptoms in these diseases and is an absolute indication. On the ketogenic diet, their bodies would consume their own protein stores for fuel, leading to ketoacidosisand eventually coma and death. The ketogenic diet is usually initiated in combination with the patient's existing anticonvulsant regimen, though patients may be weaned off anticonvulsants if the diet is successful.

Some evidence of synergistic benefits is seen when the diet is combined with the vagus nerve stimulator or with the drug zonisamideand that the diet may be less successful in children receiving phenobarbital.

The ketogenic diet is not a benign, holistic, or natural treatment for epilepsy; as with any serious medical therapy, complications may result. Long-term use of the ketogenic diet in children increases the risk of slowed or stunted growth, bone fractures, and kidney stones. Like many anticonvulsant drugs, the ketogenic diet has an adverse effect on bone health.

Many factors may be involved such as acidosis and suppressed growth hormone. A class of anticonvulsants known as carbonic anhydrase inhibitors topiramatezonisamide are known to increase the risk of kidney stones, but the combination of these anticonvulsants and the ketogenic diet does not appear to elevate the risk above that of the diet alone.

In adolescent and adults, common side effects reported include weight loss, Recetas dieta blanda no astringente, dyslipidemia Que es la dieta cetogenica wikipedia, and in women, dysmenorrhea. The ketogenic diet is a medical nutrition therapy that involves participants from various disciplines.

Team members Que es la dieta cetogenica wikipedia a registered paediatric dietitian who coordinates the diet programme; a paediatric neurologist who is experienced in offering the ketogenic diet; and a registered nurse who is familiar with childhood epilepsy. Additional help may come Que es la dieta cetogenica wikipedia a medical social worker who works with the family and a pharmacist who can advise on the carbohydrate content of medicines.

Lastly, the parents and other caregivers must be educated in many aspects of the diet for it to be safely implemented. Implementing the diet can present difficulties for caregivers and the patient due to the time commitment involved in measuring and planning meals.

Since any unplanned eating can potentially break the nutritional balance required, some people find the discipline needed to maintain the diet challenging and unpleasant. Some people terminate the diet or switch Que es la dieta cetogenica wikipedia a less demanding diet, like the Que es la dieta cetogenica wikipedia Atkins diet or the low-glycaemic index treatment diet, because they find the difficulties too great.

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The Johns Hopkins Hospital protocol for initiating the ketogenic diet has been widely adopted. At the initial consultation, patients are screened for conditions that may contraindicate the diet. A dietary history is obtained and the parameters of the diet selected: the ketogenic ratio of fat to combined Que es la dieta cetogenica wikipedia and carbohydrate, the calorie requirements and the fluid intake. The day before admission to hospital, the proportion of carbohydrate in the diet may be decreased and the patient begins fasting after his or her evening meal.

The following breakfast and lunch are similar, and on the second day, the "eggnog" dinner is increased to two-thirds of a typical meal's caloric content. By the third day, dinner contains the full calorie quota and is a standard ketogenic meal Que es la dieta cetogenica wikipedia "eggnog". After a ketogenic breakfast on the fourth day, the patient is discharged.

Dieta cetogénica

Where possible, the patient's current medicines are changed to carbohydrate-free formulations. When in the hospital, glucose levels are checked several times daily and the patient is monitored for signs of symptomatic ketosis which can be treated with a Dietas rapidas quantity of orange juice.

Lack of energy and lethargy are common, but disappear within two weeks. Variations on the Johns Hopkins protocol are common. The initiation can be performed using outpatient clinics rather than requiring a stay in hospital. Often, no initial fast is used fasting increases the risk of acidosishypoglycaemia, and weight loss. Rather than increasing meal sizes Que es la dieta cetogenica wikipedia the three-day initiation, some institutions maintain meal size, but alter the ketogenic ratio from to If the diet does not begin with a fast, the time for half of the patients to achieve an improvement is longer two weeksbut the long-term seizure reduction rates are unaffected.

After initiation, the child regularly visits the hospital outpatient clinic where they are seen by the dietitian and neurologist, and various tests and examinations are performed. Que es la dieta cetogenica wikipedia are held every three months for the first year and then every six months thereafter.

Infants under one year old are seen more frequently, with the initial visit held after just two to four weeks. This fine-tuning is Que es la dieta cetogenica wikipedia done over the telephone with the hospital dietitian [19] and includes changing the number of calories, altering the ketogenic ratio, or adding some MCT or coconut oils to a classic diet.

Que es la dieta cetogenica wikipedia

A short-lived increase in seizure frequency may occur during illness or if ketone levels fluctuate. The diet may be modified if seizure frequency remains high, or the child is Que es la dieta cetogenica wikipedia weight.

Even "sugar-free" food can contain carbohydrates such as maltodextrinsorbitolstarchand fructose. The sorbitol content of suntan lotion and other skincare products may be high enough for some to be absorbed through the skin and thus negate ketosis. This is Que es la dieta cetogenica wikipedia by lowering the ketogenic ratio until urinary ketosis is no longer detected, and then lifting all calorie restrictions.

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When the diet is required to treat certain metabolic diseases, the duration will be longer. The total diet duration is up to the treating ketogenic diet team and parents; durations up to 12 years have been studied and found beneficial.

The length of time until recurrence is highly variable, but averages two years. Of those who have a recurrence, just over half can regain freedom from seizures either with anticonvulsants or by returning to the ketogenic diet. Adelgazar 20 kg: Laxantes para adelgazar rapido caseros san telmo. The ketogenic diet is Que es la dieta cetogenica wikipedia high- fatadequate- proteinlow-carbohydrate diet that in medicine is used primarily to treat difficult-to-control refractory epilepsy in children.

The diet forces the body to burn fats rather than carbohydrates. Normally, the carbohydrates contained in food are converted into glucosewhich is then transported around the body and is particularly important in fueling brain function. However, if little carbohydrate remains in the diet, the liver converts fat into fatty acids and ketone bodies. The ketone bodies pass Que es la dieta cetogenica wikipedia the brain and replace glucose as an energy source.

An elevated level of ketone bodies in the blood, a state known as ketosisleads to a reduction in the frequency of epileptic seizures. The original therapeutic diet for paediatric epilepsy provides just enough protein for body growth and repair, and sufficient calories [Note 1] to maintain the correct weight for age and height. The classic therapeutic ketogenic diet was developed Que es la dieta cetogenica wikipedia treatment of paediatric epilepsy in the s and was widely used into the next decade, but its popularity waned with the introduction of effective anticonvulsant medications.

This classic ketogenic diet contains a ratio by weight of fat to combined protein and carbohydrate. This is achieved by excluding high-carbohydrate foods such as starchy fruits and vegetables, bread, pasta, grains, and sugar, while increasing the consumption of foods high Dietas faciles fat such as nuts, cream, and butter.

However, medium-chain triglycerides MCTs —made from fatty acids with shorter carbon chains than LCTs—are more ketogenic. A variant of the classic diet known as the MCT ketogenic diet uses a form of coconut oilwhich is rich in MCTs, to provide around half the calories. As less overall fat is needed in this variant of the diet, a greater proportion of carbohydrate and protein can be consumed, allowing a greater variety of food choices.

InHollywood producer Jim Abrahamswhose son's severe epilepsy was effectively controlled by the diet, created the Charlie Foundation for Ketogenic Therapies to further promote diet therapy. Publicity included an appearance on NBC's Dateline program and The foundation sponsored a research study, the results of which—announced Adelgazar 15 kilos —marked the beginning of renewed scientific interest in the diet.

Possible therapeutic uses for the ketogenic diet have been studied for many additional neurological disorders, some of which include: Alzheimer's diseaseamyotrophic lateral sclerosisautismbrain cancerheadache, neurotraumapain, Parkinson's diseaseand sleep disorders.

These occur when cortical neurons fire excessively, hypersynchronouslyor both, leading to temporary disruption of normal brain function. This might affect, for example, Que es la dieta cetogenica wikipedia muscles, the senses, consciousness, or Que es la dieta cetogenica wikipedia combination.

A seizure can be Que es la dieta cetogenica wikipedia confined to one part of the brain or generalised spread widely throughout the brain and leading to a loss of consciousness. Epilepsy can occur for a variety of reasons; some forms have been classified into epileptic syndromesmost of which begin in childhood.

Epilepsy is considered refractory not yielding to treatment when two or three anticonvulsant drugs have failed to control it. When drugs fail, other options include epilepsy surgeryvagus nerve stimulationand the ketogenic diet.

The ketogenic diet is a mainstream dietary therapy that was developed to reproduce the success and remove the limitations of the non-mainstream use of fasting to Que es la dieta cetogenica wikipedia epilepsy. Physicians of ancient Greece treated diseases, including epilepsy, by altering their patients' diet. An early treatise in the Hippocratic CorpusOn the Sacred Diseasecovers the disease; it dates from c.

Its author argued against the prevailing view that epilepsy was supernatural in origin and cure, and proposed that dietary therapy had a rational and physical basis. The first modern study of fasting as a treatment for epilepsy was in France in Two benefited enormously, but most failed to maintain compliance with the imposed restrictions.

Que es la dieta cetogenica wikipedia

The diet improved the patients' mental capabilities, in contrast to their medication, potassium bromidewhich dulled the mind. Around this time, Bernarr Macfaddenan American exponent of physical culturepopularised the use of fasting to restore health.

His disciple, the osteopathic physician Dr. Hugh William Conklin of Battle Creek, Michiganbegan to treat his epilepsy patients by recommending fasting. Conklin conjectured that Que es la dieta cetogenica wikipedia seizures were caused when a toxin, secreted from the Peyer's patches in the intestines, was discharged into the bloodstream.

Conklin's fasting therapy was adopted by neurologists in mainstream practice. Ina Dr McMurray wrote to the New York Medical Journal claiming to have successfully treated epilepsy patients with a fast, followed by a starch- and sugar-free diet, since Inprominent endocrinologist Henry Rawle Geyelin reported his experiences to the American Medical Association convention. He had seen Conklin's success first-hand and had attempted to reproduce the results in 36 of his own patients.

He achieved similar results despite having studied the patients for only a Que es la dieta cetogenica wikipedia time. Further studies in the s indicated that seizures generally returned after the fast. Charles P.

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Howland used the money to fund research undertaken by neurologist Stanley Cobb and his assistant William G. InRollin Turner Woodyatt reviewed the research on diet and diabetes. Russell Morse Wilder, at the Mayo Clinicbuilt on this research and coined the term "ketogenic diet" to describe a diet that produced a high level of ketone bodies in the blood ketonemia through an excess of fat and lack of carbohydrate.

Wilder hoped to obtain the benefits of fasting in a dietary therapy that could be maintained indefinitely. His trial on a few epilepsy patients in was the first use of the ketogenic diet as a treatment for epilepsy. Peterman's work in the s established the techniques for induction and maintenance of the diet.

Peterman documented positive effects improved alertness, behaviour, and sleep and adverse effects nausea and vomiting due to excess ketosis. Bythe diet had also been studied in teenagers and adults. Clifford Joseph Barborka, Sr. Although the adult results are similar to modern studies of children, they did not compare as well to contemporary studies.

Barborka concluded that adults were least likely to benefit from the Que es la dieta cetogenica wikipedia, and the use of the ketogenic diet in adults was not studied again until During the s and s, when the only anticonvulsant drugs were the sedative bromides discovered and phenobarbitalthe ketogenic diet was widely used and studied. This changed in when H. Houston Merritt, Jr. With the introduction of sodium valproate in the s, drugs were available to neurologists that were effective Que es la dieta cetogenica wikipedia a broad range of epileptic syndromes and seizure types.

The Que es la dieta cetogenica wikipedia of the ketogenic diet, by this time restricted to difficult cases such as Lennox—Gastaut syndromedeclined further.

Dieta Cetogénica, Conceptos básicos

Que es la dieta cetogenica wikipedia In the s, medium-chain Que es la dieta cetogenica wikipedia MCTs were found to produce more ketone bodies per unit of energy than normal dietary fats which are mostly long-chain triglycerides.

The oil was mixed with at least twice its volume of skimmed milk, chilled, and sipped during the meal or incorporated into food. He tested it on 12 children and adolescents with intractable seizures. Most children improved in both seizure control and alertness, results that were similar to the classic ketogenic diet. Gastrointestinal upset was a problem, which led one patient to abandon the diet, but meals were easier to prepare and better accepted by the children.

The two-year-old suffered from epilepsy that had remained uncontrolled by mainstream and alternative therapies. Abrahams discovered a reference to the ketogenic diet in an epilepsy guide for parents and brought Charlie to John M.

Que es la dieta cetogenica wikipedia

Freeman at Johns Hopkins Hospitalwhich had continued to offer the therapy. Under the diet, Charlie's epilepsy was rapidly controlled and his developmental progress resumed. This inspired Abrahams to create the Charlie Foundation to promote the diet and fund research. There followed an explosion of scientific interest in the diet. InAbrahams produced a TV movie, Dietas rapidas Do No Harmstarring Meryl Streep, in which a young boy's intractable epilepsy is Que es la dieta cetogenica wikipedia treated by the ketogenic diet.

Bythe ketogenic diet was available from around 75 centres in 45 countries, and less restrictive variants, such as the modified Atkins diet, were in use, particularly among older children and adults. The ketogenic diet was also under investigation for the treatment of a wide variety of disorders other than epilepsy.

These studies generally examined a cohort of patients recently treated by the physician a retrospective study and selected patients who had successfully maintained the dietary restrictions. However, these studies are difficult to compare to modern trials. One reason is that these older trials suffered from selection biasQue es la dieta cetogenica wikipedia they excluded patients who were unable to start or maintain the diet and thereby selected from patients who would generate better results.

In an attempt to control for this bias, modern study design prefers a prospective cohort the patients in the study are chosen before therapy begins in which the results are presented for all patients regardless of whether Que es la dieta cetogenica wikipedia started or completed the treatment known as intent-to-treat analysis.

Another difference between older and newer studies is that the type of patients treated with the ketogenic diet has changed over time. When first developed and used, the ketogenic diet was not a treatment of last resort; in contrast, the children in modern studies have already tried and failed Que es la dieta cetogenica wikipedia number of anticonvulsant drugs, so may be assumed to have more difficult-to-treat epilepsy.

Early and modern studies also differ because the treatment protocol has changed.

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Concerns over child health and growth led to a relaxation of the diet's restrictions. A study with an intent-to-treat prospective design was published in by a team from the Johns Hopkins Hospital [20] and followed-up Que es la dieta cetogenica wikipedia a report published in The study enrolled children.

Those Dietas rapidas had discontinued the diet by this stage did so because it was ineffective, too restrictive, or due to illness, and most of those who remained were benefiting from it. During this period, the most common reason for discontinuing the diet was because the children had become seizure-free or significantly better.

Those remaining on the diet after this duration were typically not seizure-free, but had had an excellent response.

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It is possible to combine the results of several small studies to produce evidence that is stronger than that available from each study alone—a statistical method known as meta-analysis.

One of four such analyses, conducted inlooked at 19 studies on a total of 1, patients. A Cochrane systematic review in found and analysed eleven randomized controlled trials of ketogenic diet in people with Que es la dieta cetogenica wikipedia for whom drugs failed to control their seizures. The other trials compared types of diets or ways of introducing them to make them more tolerable. A systematic review in looked at 16 studies on the ketogenic diet in adults. It concluded that the treatment was becoming more popular for that group of patients, that the efficacy in adults was similar to children, the side effects relatively mild.

However, many patients gave up with the diet, for various reasons, and the quality of evidence was inferior to studies on children. Health issues include high levels of low-density lipoproteinhigh total cholesteroland weight loss. The ketogenic diet is indicated as an adjunctive additional treatment in children and young people with drug-resistant epilepsy. Some clinicians consider the two less restrictive dietary variants—the low glycaemic index treatment and the modified Atkins diet—to be more appropriate for adolescents and adults.

These include Dravet syndromeinfantile spasmsQue es la dieta cetogenica wikipedia epilepsyand tuberous sclerosis complex. Several possible explanations exist for this gap between evidence and clinical practice. Because the ketogenic diet alters the Que es la dieta cetogenica wikipedia metabolism, it is a first-line therapy in children with certain congenital metabolic diseases such as pyruvate dehydrogenase E1 deficiency and glucose transporter Que es la dieta cetogenica wikipedia deficiency syndrome[35] which prevent the body from using carbohydrates as fuel, leading to a dependency on ketone bodies.

The ketogenic diet is beneficial in treating the seizures and some other symptoms in these diseases and is an absolute indication. High protein diet plan basics.

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